When choosing nonsteroidal anti-inflammatory drugs (NSAIDs), it is very important to understand their classifications and effects on the human body. Based on the type of COX enzyme they target, NSAIDs can be divided into the following two categories:
Non-selective NSAIDs: These drugs inhibit the activity of both COX-1 and COX-2 enzymes. Common non-selective NSAIDs include ibuprofen, diclofenac, indomethacin, ketoprofen (phenylpropionic acid), ketorolac, mefenamic acid, naproxen, and piroxicam.
COX-2 inhibitors: These drugs selectively inhibit the activity of COX-2 only, without affecting COX-1. Therefore, compared to non-selective NSAIDs, COX-2 inhibitors carry a lower risk of stomach bleeding. Common COX-2 inhibitors include Arcoxia and Celebrex.
It is important to note that most commonly used NSAIDs (such as diclofenac tablets and mefenamic acid capsules) require a doctor's prescription to be purchased at a pharmacy. However, some NSAIDs (like ibuprofen tablets) can be bought directly at registered pharmacies under the supervision of a licensed pharmacist.
We hope the above explanation helps the public better understand the classification and uses of NSAIDs.